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It also increases aquaporin-4 (AQP-4) involved in glial edema (47), and poli ADP-ribose polymerase-1 (PARP-1) that favors necrosis through glial activation (48)
The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
Lancet 370 , 263271 (2007)
Is Glutathione approved for human use
Glutathione plays a key role in eliminating toxins, protecting cells, and restoring overall health and well-being
Adaptation to oxidative stress: quinone-mediated protection of signaling in rat lung epithelial L2 cells
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