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As NAD+ supplementation research has expanded dramatically, the discovery that NNMT depletes NAD+ precursors specifically in metabolically dysfunctional fat tissue provides a targeted intervention point

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NAD precursors (NMN, NR): directly raise NAD

Their white epididymal and brown interscapular adipose tissues were dissected, weighed, and frozen in liquid nitrogen for later RNA analysis

Cell culture studies have shown that NNMT inhibition increases intracellular NAD+ levels, enhances sirtuin activity, and shifts adipocyte metabolism toward greater fatty acid oxidation