c tirzepatide C-terminal Deamidation | High-Purity Diabetes Drug Impurity Analysis Tirzepatide - Wikipedia

Hwang T-S, Song J

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The high variability (CV 50%80%) was accepted because: (1) the patient population was already dose-optimized, (2) growth hormone suppression integrates over time (AUC-driven), and (3) the indication did not require treatment-nave dose finding

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When checking a company's ability to make something, they should look at their peptide synthesis platforms, processing technologies (RP-HPLC, preparative chromatography), and analytical characterization methods (mass spectrometry, amino acid analysis)