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Because the body's stress response runs through the hypothalamic-pituitary-adrenal axis, support that helps the brain stay clear under pressure may make that response feel more manageable, a stress cascade described in detail by Harvard Health Publishing

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Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1

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Thats why there are reviews with titles like this: plant-based pregnancies: danger or panacea