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Since then, hundreds of preclinical studies have reported reduced intake, reward or relapse across a wide range of substances, including alcohol, nicotine, cocaine, amphetamines and opioids

Both approaches can provide safe, effective GLP-1 therapy when matched to appropriate patient populations

The ATG12-ATG5-ATG16L1 complex drives membrane expansion (18), whereas microtubule-associated protein 1 light chain 3 (LC3) is conjugated to phosphatidylethanolamine, converting LC3-I to membrane-bound LC3-II, a hallmark of autophagosomes (19)