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It interacts with multiple systems in the body including the nitric oxide (NO) pathway, growth hormone receptors, and angiogenic regulators like VEGF (vascular endothelial growth factor) to promote tissue repair, reduce oxidative stress, and modulate the immune response

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The dosing approach is gradual

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220 However, the total depletion of NAD + could be very toxic to noncancerous cells, thereby it has been considered to rescue them using NAPRT precursor, nicotinic acid