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They did note that deep lesions had altered bacterial profiles (less Lactobacillus , more Alishewanella , Enterococcus and Pseudomonas ), suggesting that different lesions may support different bacterial populations 31
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Studied doses typically range from 900 to 1,500 mg daily, divided into two or three doses to minimize gastrointestinal side effects, though it's important to note that berberine has poor and variable oral bioavailability
In the landmark LEADER trial , liraglutide was shown to reduce the risk of major cardiovascular events including heart attack, stroke, and cardiovascular death in people with type 2 diabetes at high cardiovascular risk
