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Nausea, vomiting, diarrhea, and constipation affect a substantial proportion of patients, and they are the primary reason patients discontinue treatment

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Based on a minimum clinically important change (MCIC) of just over 3-point improvement in UPDRS [23], the current model shows an approximate duration of effect for approved doses of SC apomorphine of 60 to 90 min, and just under 90 min for the approved 30-mg dose of SL apomorphine (Fig