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CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion

DHA binds to the G protein-coupled receptor 40 in hepatocytes downregulating the sterol regulatory element-binding protein 1 (SRBEP-1) that controls gene expression of lipogenic enzymes (54, 57, 58), thus decreasing triglycerides and cholesterol accumulation in liver caused by alcohol consumption (55, 57)

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This link is believed to be primarily mediated by the metabolic, vascular, and inflammatory pathways associated with diabetes, which contribute to the pathogenesis of neurodegeneration