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Pinto, C

showed that in cultured rat ventricular myocytes, trimetazidines beneficial effects were only observed when cells were undergoing hypoxia and not during normoxia, highlighting trimetazidine as a metabolic regulator that would not increase mitochondrial function in healthy states [123]

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Micevic has also been supported by the Dermatology Foundation and American Skin Association

Additionally, vitamin D inhibits the expression of RAAS-related receptors through VDR-mediated negative feedback mechanisms, indirectly exerting cardiorenal protective effects (40)