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Even a recent 2026 review concludes the same thing that GHK-Cu appears safe but the evidence is largely preclinical and comprehensive human RCTs are lacking (Wojcieszuk et al., 2026)

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Skin Health, Skin Elasticity, and Aging Skin Concerns A review of topical anti-aging peptide studies reported that Cu-GHK formulations were associated with improved visible signs of aged and sun-damaged skin, including skin density, thickness, elasticity, humidity, and wrinkle appearance in 12-week studies involving 71 or 41 women [2]

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Despite the predominant pro-tumorigenic roles attributed to iCAFs in various studies, a cluster of tumour-restrictive iCAFs characterised by high expression of osteoglycin was identified [237]

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