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Oxoproline catalytically activates the uptake of amino acids through the placental barrier, and the transfer of amino acids through the bloodbrain barrier is activated by oxoproline (75)

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There is a theoretical concern that aggressive senolytic clearance could remove this anti-tumor senescence signal, potentially accelerating tumor growth in individuals with pre-malignant cells

39:12.14 View Abstract [12] Montuschi P, Barnes P and Roberts L

While this is protective against age-related hyperfunction, it theoretically risks blunting the anabolic responses required for new synaptic formation, muscle hypertrophy, or exercise adaptation in subjects who are not already biologically aged

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