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5-Amino-1MQ works through a third lever that most people haven't thought about and that's exactly why it stacks so well with both

Also known as 5 amino 1 methylquinolinium, its structure has made it a subject of interest for investigating NNMT activity and related cellular metabolic pathways

Current status: preclinical research compound, not approved for human use

BMC Geriatr

5-Amino-1MQ inhibits NNMT activity, preserving nicotinamide for NAD+ synthesis and preserving SAM for epigenetic methylation producing a metabolic state in pre-clinical models that has been described as functionally resembling caloric restriction or elevated physical activity at the cellular level