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Although no significant changes in leptin or adiponectin levels have been observed in studies of IF in MS, an observed difference in T-cell subsets in intestines might explain the immunological effects of IF that have been reported in studies (60), which was also a kind of possible therapy for MS (59)

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Exclusion criteria included non-randomized studies, trials enrolling pediatric populations, and studies of less than 1,000 patients or less than 12 month follow up