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Clinical studies show users of the medications can lose between 5% and 20% of their body weight on the medications over time

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This can cause plasma protein leakage into brain parenchyma, triggering neuroinflammation that subsequently leads to neuronal damage 92

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A few patients very infrequently can be allergic to it

These gaps are why regulators take the time they do, and why grey-market retatrutide is unsafe