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The concept dates back to the 1830s

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3.2 Antioxidant and anti-inflammatory roles of vitamin D in PCOS PCOS has been characterized by a well-documented bidirectional relationship with vitamin D status

Metformin has been associated with reduced vitamin B12 absorption through effects on calcium-dependent membrane action in the terminal ileum, which may be relevant for patients on chronic metformin therapy

Most antibiotics are processed through the liver or kidneys

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