are oral glp-1 effective GLP-1s: Brace yourself for the next wave A new chapter in obesity

Lets look at what was going on in obesity at the time to better understand this, starting with the revenue of obesity drugs during 2007-2016

not statistically significant [6]

BMI 25.0 to 26.9 (overweight, below threshold)

K.BennellK.Bierma-ZeinstraS

Human studies Five human studies investigated the effect of specific diets/nutritional programs on ES-induced outcomes

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs