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Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer

Endogenous L-carnitine (LC) and its derivative acetyl-L-carnitine (ALC) play antidepressant roles by improving brain energy metabolism, regulating neurotransmitters and neural plasticity

Whether this mechanism is commonly employed for a variety of substrates and whether monothiol mechanisms (i) and (ii) are really relevant for the reduction of other non-glutathione disulfide substrates remains to be analyzed