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Importantly, the evidence on Graves disease is still preliminary and limited

PMID:14986904, Suppl 4 Gillespie CM, Merkel AL, Martin AA: Effects of insulin-like growth factor-I and LR3IGF-I on regional blood flow in normal rats

The microbiota metabolite TMAO exacerbates oxidative stress by decreasing the levels of superoxide dismutase, increasing the levels of malondialdehyde and glutathione peroxidase, and producing pro-inflammatory cytokines 137

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Biomolecules 14:926

Interestingly, inhibition of adrenoceptor beta 2 (ADRB2) has been shown to attenuate fibrosis by suppressing SMAD2/3 phosphorylation and promoting proteasomal degradation of phospho-SMAD2/3 in lung fibroblasts [42]