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Furthermore, using a murine cholangitis model, the researchers clarified the underlying mechanisms: butyrate activates peroxisome proliferator-activated receptor delta (PPARD) to promote fatty acid -oxidation (FAO)-mediated metabolic reprogramming

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The most evident and generally accepted detrimental effect of iron accumulation is the production of ROS via Fenton reaction, in which hydrogen peroxide is converted into hydroxyl radicals in the presence of ferrous iron [92]

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