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A 2023 study in Fertility and Sterility found that women with PCOS using semaglutide experienced an average 10 percent body weight reduction over 6 months, along with improvements in menstrual regularity and anti-mllerian hormone (AMH) levelsa marker of ovarian reserve

Both estrogen and GLP-1 receptor activation stimulate this same pathway, but rather than simply unlocking the door, they help widen the doorway itself, making the cell more responsive to insulin's signal and better equipped to take up glucose efficiently

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