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Professor Ania Jastreboff, MD, PhD Yale University provided an overview #ADA2026 of the TRIUMPH-1 trial for Retatrutide, the investigational triple G medicine from Eli Lilly and Company The unique trial design provided insights beyond #weightloss #obesity and also encompassed relevant endpoints for co-morbidities such as knee osteoarthritis and obstructive sleep apnea, two comorbidities highly sensitive to weight loss

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Polyubiquitination of signaling molecules such as TRAF2, TRAF6, RIP-1, and NEMO activates the TAK1 and IB kinase (IKK) complexes, leading to NF-B activation and pro-inflammatory cytokine production

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