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Integration also amplifies the challenges of reproductive cohorts: high dimensionality under modest n, partially missing omics blocks (cycle cancellation, biopsy selection, embryo availability), center/protocol batch structure, and heterogeneous endpoints (biochemical pregnancy vs live birth vs cumulative live birth)

A formal review protocol was developed prior to initiating the literature search, although it was not registered in PROSPERO, which is acknowledged as a limitation

Dealing with them may be disturbing and cause one to lose self-assurance

Magnetic resonance imaging (MRI), highly sensitive to tissue iron, is used as a non-invasive method for severity grading and therapeutic monitoring in patients with known or suspected iron overload

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You inject the full volume but get reduced or zero effect