glp-1 landscape glp1agonists #obesitytreatment #healthcareinnovation #novonordisk #elililly GLP-1 Food Landscape: 4 Trends

Inagaki N, Seino Y, Takeda J, et al

pharmacodynamic overlap possible via shared antioxidant pathways Primary concern / IV glutathione and liver-enzyme monitoring in patients on dulaglutide Monitoring recommended / LFTs at baseline and periodically when adding high-dose IV glutathione Evidence gap / no randomized controlled trial has tested the combination directly GLP-1 antioxidant effect / dulaglutide independently reduces oxidative stress markers in human studies Key guideline / ADA Standards of Care 2024 does not list glutathione as contraindicated with GLP-1 agents Bottom line / low-dose oral glutathione appears safe

M.KhodeerD

doi: 10.1155/2018/3901619 22

Increased amounts of IL-6 increase free-flowing fatty (FFA) synthesis and help inhibit insulin pathway signalling, which reduces the responsiveness of insulin in the liver and muscles

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