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Side effects usually show up early, often within the first few doses, and tend to ease as your body adjusts to the medication

Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial, Lancet (2026) [PubMed abstract] Tirzepatide (Zepbound) review

As phase II detoxification enzymes, arthropod GSTs confer pesticide resistance through direct metabolism or sequestration of pesticides and indirectly by providing protection against oxidative stress induced by synthetic pesticides [22]

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PMID 16294345