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sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

[DOI] [PubMed] [Google Scholar] 163.Magnani M

However, long-term safety of MB hasnt been studied extensively, so periodic evaluation is recommended

Navarro SL, Chang J-L, Peterson S, Chen C, King IB, Schwarz Y, et al

& Hamed, A

doi: 10.1530/REP-20-0298 74 ReiterRJTanDXKorkmazAErrenTCPiekarskiCTamuraHet al