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The metabolites for which serum levels differed between controls and schizophrenia patients are listed in Table 2

Their normalization should ostensibly improve muscular function

The one compound that appeared to reduce bacterial burden did so because infected macrophages were washed away after 24-h treatment, rather than through bactericidal activity against intracellular bacteria

However, up to 40% of patients do not achieve satisfactory relief, prompting investigation of combination therapy, most commonly adding a second agent (e.g., duloxetine plus pregabalin), which can yield incremental pain reduction of 1020% but with increased risk of sedation, dizziness and drug interactions [64]

Y.SchluesenerH.ZhangZ

doi: 10.1016/j.cell.2020.02.052 41 HuB.GuoH.ZhouP.ShiZ