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Tirzepatide does not worsen kidney function and may offer cardio-renal protective benefits similar to other GLP-1 agonists, which have demonstrated reduced kidney disease progression in multiple randomized trials

Bold values indicate the most clinically significant gut microbiota-derived uremic toxins and their associated microbial genera, which have been validated in human observational studies or human mechanistic studies (as specified in the Evidence Level column)

This occurs when bleeding happens in the stomach or upper intestines, altering stool color

doi:10.1016/j.ejphar.2020.173368 Yilmaz H, Sahin S, Sayar N, et al