Despite decades of research, RAs etiology remains only partially understood, and current therapeutic strategies, including biologic agents, often show variable efficacy and high failure rates across patients (67, 193)
A palmitoylationdepalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis
55 GalluzziL.Bravo-San PedroJ
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To synthesize the compounds, alkoxide, alkyl and heterocycle groups were added to ring A of the chalcone structure to maximize the enzyme inhibition activity
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