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They illustrated that 100 mg/d riboflavin supplementation during 3 months had a similar effect to propranolol intervention, and also riboflavin supplementation would be a safe intervention for migraine prevention (35)

Regulation / Reduction of pigment production

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[7] [9] Patients with hemochromatosis or other iron overload disorders should not receive large doses of ascorbic acid, as it can enhance iron absorption and exacerbate tissue deposition

3.1.7 Voltage-dependent anion channels in ferroptosis and oxidative stress Voltage-dependent anion channels (VDACs), membrane pore proteins located in the outer mitochondrial membrane, facilitate ion and metabolite transport in eukaryotic cells (39)