Retatrutide (research code LY3437943) is a single-molecule triple agonist that activates the GIP receptor, the GLP-1 receptor, and the glucagon receptor
An animal study also shows that knockout specifically of SIRT1 in myeloid cells alleviates synovial inflammation and bone destruction of RA by decreasing Th1 and Th17 differentiation (304)
Prior authorization for Wegovy typically requires documented obesity (BMI 30) or overweight with comorbidity, plus evidence of previous lifestyle intervention attempts
For tirzepatide with its five-day half-life, steady state arrives slightly sooner, around 20-25 days
The effect appears to be related to curcumin's ability to reduce oxidative stress and inflammation in the intestinal cells that produce GLP-1
Given this information, emerging therapies which target GSH homeostasis such as N-acetylcysteine (NAC), GSH esters, or activation of antioxidant response elements may provide new avenues to interrupt oxidant-driven inflammation in these diseases
