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The 143B cells were cultured to 80% confluence, and incubated with 200 M hypoxyprobe and PBS, Ru(II)-OH, NP2, or NP4 (Ru 10 M) under hypoxia condition for 12 h

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Im just saying, lets be careful in select patients because I think theres the potential to do harm. You found hypotension was most common among patients over 65 and those with diabetes

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Side effects are rare and typically limited to mild bruising at the injection site or temporary coolness in the arm during infusion