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MK-677 is a non-peptide spiropiperidine previously shown to be functionally and mechanistically indistinguishable in vitro and in vivo from the potent peptide GHS GHRP-6.1 MK-677 has been found to elevate GH levels, as well as IGF-I and cortisol levels, in dogs after oral administration:6 this stimulatory effect appears to depend on the presence of an intact pituitary.7 Previous studies in humans demonstrated that daily oral administration of MK-677 in healthy older adults,8 GH-deficient adults9 for 4 weeks, and GH-deficient children10 for 7 days increased serum GH, IGF-I, and IGF binding protein (IGFBP)-3 concentrations