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That is why many patients need an ongoing plan that includes: daily SPF pigment-conscious skincare maintenance treatments long-term trigger management In other words, melasma is often managed, not permanently cured

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Mechanistic studies further propose that increased intestinal permeability (leaky gut) may allow bacterial metabolites and endotoxinssuch as lipopolysaccharideto enter the circulation and activate systemic and neuroinflammatory pathways (Doenyas, 2018