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People lose an average 8% of their starting weight in 56 weeks on the maintenance dose

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doi: 10.1007/s40618-021-01635-z 35 AgarwalRFilippatosGPittBAnkerSDRossingPJosephAet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 209.Wang G-E, Li Y-F, Zhai Y-J, Gong L, Tian J-Y, Hong M, et al

Published Aug 13, 2025

Three principal amylin receptor subtypes exist [13] : AMY1 Receptor CTR + RAMP1 Primary receptor in area postrema (brainstem satiety center) [14] AMY2 Receptor CTR + RAMP2 Expressed in cardiovascular tissues and central nervous system [14] AMY3 Receptor CTR + RAMP3 Found in peripheral tissues including gastrointestinal tract [14] Cagrilintide binds to and activates these receptors with high affinity, triggering intracellular signaling cascades involving cyclic AMP (cAMP) and calcium mobilization [4]