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It should be noted that there is some speculation, which is not supported by strong human data, that anti-VEGF macular degeneration treatments may exert systemic effects and negatively impact vascular health by leaking from the eye

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Cell Death Differ 10:249256 Lang KS, Lang PA, Bauer C et al (2005) Mechanisms of suicidal erythrocyte death

When assessed for anti-Chinese hamster ovary (CHO) cell protein antibodies, of 229 treated subjects, 3 showed an upward trend in antibody titer over time and 10 showed repeated but transient elevations of antibodies

Interrupting this pattern for even one week can reset eating habits and make dietary adherence harder, undoing progress from previous months

2021, doi: 10.1038/s41598-021-95687-z