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The reverse LC-MS/MS response curve ( y = 1.0088 x 0.014, R 2 = 0.9999) was linear in molar ratios between 0.043 and 8.65 with Y -axis being peak area ratio [ A ([ 15 N 13 ]-CNCbl)/ A (CNCbl)] and X -axis being the molar ratio [n([ 15 N 13 ]-CNCbl)/n(CNCbl)]