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There is compelling evidence that arsenic metabolism and toxicity vary because of genetic factors (see discussion in Chapter 5)

Glycemic improvements often precede significant weight changes, and individual responses vary based on baseline metabolic status, dosing regimen, and adherence to lifestyle modifications

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Lipo C is contraindicated in patients with Lebers hereditary optic neuropathy (cyanocobalamin can worsen this condition), active B12-dependent malignancies, severe kidney disease (impaired methionine clearance), or known hypersensitivity to any component