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The observed effect was attributed to DSePA-mediated suppression of DNA damage response pathways and, in turn, the inhibition of DNA repair in the irradiated lung cancer cells

Milkovic L, Zarkovic N, Marusic Z, Zarkovic K, Jaganjac M

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doi: 10.1089/neu.2012.2535

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A prudent approach is to begin orforglipron at the starting dose (likely a low titration dose) approximately one week after the last injection, titrating up as the injectable's effects wane