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4.23, 1.93) than placebo (0.36

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35 The use of GLP-1 receptor agonists should be avoided in those with a family history or personal history of medullary thyroid cancer or multiple endocrine neoplasia type 2, with rodent studies showing an increased risk

[DOI] [PubMed] [Google Scholar] 83.Pevec D., Novinscak T., Brcic L., Sipos K., Jukic I., Staresinic M., Mise S., Brcic I., Kolenc D., Klicek R

In addition, tirzepatide affects certain chemicals in the brain which in turn decreases appetite, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat)