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The symptom list overlaps almost perfectly with the symptoms people blame on "high B12" which is part of why this connection often gets missed

Increased irritability or feelings of low mood and anxiety

The compound has served as a biochemical tool to probe how NNMT activity intersects with insulin signaling and glucose utilization pathways in research settings

2 Patients of certain bariatric procedure types may have limited intrinsic factor, 3 a substance produced in the lower part of the stomach, which is needed to absorb vitamin B 12