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It can be given in divided doses with meals, or as an extended-release formulation (Glucophage XR ) that is generally given once daily with the evening meal
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[v] A Comprehensive Preclinical In Vivo Study A preclinical study on an in vivo animal model should be conducted to assess the safety and efficacy of a drug candidate before initiating a human study
Do not delay treatment pending confirmatory tests if neurological involvement is suspected
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