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Several physiological and lifestyle factors influence your body's natural GLP-1 production and secretion

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Conversely, some case reports for exenatide 181 and semaglutide 182 described onset or relapse of depressive symptoms, which resolved when the GLP-1RAs were stopped 181,182 and recurred on medication rechallenge 181

GLP-1 RAs don't suppress insulin secretion or alter ketone metabolism in the same way, making their safety profile meaningfully different

In some respects, many people enter a game of weight-loss roulette when it comes to stopping their weight-loss medication