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This formed the basis for Black's development of the first beta-blocker, propranolol, at Imperial Chemical Industries, a chemical conglomerate with pharmaceutical laboratories in Cheshire that he joined in 1958 and stayed with until 1964 when he moved to Smith Kline and French, an American pharmaceutical company with laboratories in Hertfordshire, South East England

These approaches have relied on the specific labeling of -cells using enzymes, cell receptors, or surface structures that are predominantly or exclusively expressed on -cells [16]

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