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doi: 10.2174/0929867324666170718104412 93 NaeimiSAHajimehdipoorHSaberS

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Applicability : Effective for both men with ED and women with Hypoactive Sexual Desire Disorder (HSDD), especially when traditional PDE-5 inhibitors fall short

Circadian Rhythm In parallel with cortisol, ACTH levels vary in an endogenous circadian rhythm, reaching a peak between 06.00-09.00h, declining through the day to a nadir between 23.00h-02.00h, and beginning to rise again at about 02.00-03.00h