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We walk through the biology that makes GLP-1RAs a plausible therapeutic in HS, the study's contributions, and the important questions that prospective studies will still need to answer

Circulation 2022;145:565-74.PubMed 73

Wright et al

Tirzepatide 15 mg discontinuation runs 6-8% in trials

Nausea that limits oral intake Vomiting within 2448 hours of planned anesthesia Persistent bloating or early satiety Unexplained weight loss or erratic glucose readings New or worsening reflux symptoms Preoperative plan clinics provide more consistency in evaluation

Because Mounjaro's effects encompass and exceed those of Januvia, adding a DPP-4 inhibitor provides negligible additional benefit