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Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study

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Analytical rigor was ensured through LC-MS/MS with isotopically labeled standards, enabling precise quantification of TMA and TMAO across biofluids (Ufnal et al., 2014)

Figure 1 The liver is one of the important target organs of metformin actions

LCs express high levels of VDR, and their phenotype and functional state are profoundly influenced by local concentrations of 1,25(OH)D [139].Studies have shown that 1,25(OH)D significantly suppresses the expression of LC surface maturation markers (such as CD80, CD86, CD40, and MHC II) as well as the chemokine receptor CCR7, thereby reducing their migratory capacity to draining lymph nodes and their ability to activate nave T cells [140]