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Semaglutide, the active ingredient in Ozempic and Wegovy, and tirzepatide, the active ingredient in Mounjaro and Zepbound, have shifted this paradigm

James Fisher explore the rise of GLP-1 medications like Ozempic and Wegovy for weight loss

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In addition, combined inhibition of Wnt, Notch, and epidermal growth factor receptor (EGFR) pathways, as well as combined inhibition of Wnt, Notch, and mitogen-associated protein kinase (MAPK), increase differentiation of Lgr5 + stem cells towards EECs and abolished differentiation of goblet cells and Paneth cells in intestinal Organoids [199] (Fig

[1] [5] Currently available GLP-1 medications in the United States include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), exenatide (Byetta, Bydureon), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GLP-1/GIP receptor agonist