Trial data shows the 8mg dose produces 21.1% weight loss with lower side effect rates: 24% nausea versus 28%, and 8.4% discontinuation versus 11.2%
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Gautron L, Elmquist JK, Williams KW
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Mild nausea or diarrhea is unlikely to compromise pill absorption enough to reduce effectiveness
Because GWAS utilize tagging SNPs, it is unclear whether rs2880961, the observed SNP with the lowest p value, is the causal SNP or if a linked SNPone not on the genotyping platformmight be responsible for the association with NAPQI IC 50