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Moreover, LRRK2 mutations in patients have been associated with increased tau phosphorylation 17,32,33,34,35 while overexpression of LRRK2 G2019S in mice also led to elevated levels of tau phosphorylation compared to overexpression of WT LRRK2 36

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Adjust : Increase if no effects (after 2 weeks)

Two separate intravenous (IV) catheters were inserted, one in each arm, and sometimes an ultrasound was used to locate the venous access in the patients arm

Although Circular ASAP2 mediates DN, nothing is known about its biological mechanism and function